Pyridoxal-5-Phosphate (P5P) is the liver’s preferred, bioavailable form of vitamin B6, essential for metabolising toxins and maintaining overall metabolic health. Unlike synthetic pyridoxine , which is excreted as waste, P5P is readily utilised by the equine body, making it a crucial addition for horses with metabolic challenges such as Cryptopyrroluria (KPU).

Why P5P matters

Hindgut dysbiosis - a common condition linked to leaky gut, faecal water syndrome, and chronic inflammation - can disrupt the natural production of P5P. This deficiency triggers a cascade of metabolic disorders that may persist despite well-intentioned interventions.

By supplementing with P5P, you provide critical support for:

• Liver detoxification: Facilitating the efficient elimination of toxins.
• Gut and immune health: Rebalancing the gut biome to support immunity.
• Neurotransmitter synthesis: Supporting serotonin, dopamine, and GABA production for mental and emotional well-being.

P5P is vital for synthesising amino acids, neurotransmitters, sphingolipids, and aminolevulinic acid, all of which play a role in maintaining cellular health and overall functionality. Naturally sourced from organisms like Euglena gracilis and Ginkgo biloba , P5P ensures your horse receives the active form of vitamin B6 their body needs.

The role of hindgut microbes

Beneficial microbes in the equine hindgut biome ferment fibre from grass forage, producing metabolites (postbiotics) that are critical for health. Among these are the activated forms of:

• Vitamin B12 (methylcobalamin)
• Vitamin B6 (Pyridoxal-5-Phosphate)

These activated forms are recognised and utilised by the liver, unlike synthetic versions, which are treated as toxins and excreted.

For a holistic approach to metabolic health, P5P works synergistically with our B12-Balance supplement, offering a complete solution for supporting your horse’s natural balance.

Key Benefits

🌿 Immune Function: Enhances the production of antibodies and white blood cells for a robust immune response.

🌿 Energy Metabolism: Supports the efficient conversion of carbohydrates, fats, and proteins into energy.

🌿 Neurotransmitter Synthesis: Facilitates the production of serotonin, dopamine, and GABA for healthy mood and cognition.

🌿 Haemoglobin Production: P5P is essential for creating haemoglobin, the protein in red blood cells that transports oxygen throughout the body.

100% pure Pyridoxal-5-Phosphate (P5P) - activated Vitamin-B6.

Source: China. UK Certificate of Analysis & Quality Control available on request.

Feed: 1g/day

• 1-level 2ml scoop = 1g
• Human Grade.