P5P *Activated Vit.B6 (Pyridoxal-5-Phosphate)

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The beneficial microbes in the hindgut biome provide essential services for the horse; they ferment the fibre from the grass forage fibre, and produce vital nutrients (metabolites/postbiotics) that the horse needs to thrive, that can't be found in food.

These include two vital vitamins in an equine-specific 'activated form - B12 , and B6 as Pyridoxal-5-Phosphate - that the gut nutrient-absorbing receptors recognise, and the liver knows what to do with, so they can then be directly utilised by the body immediately , enhancing their bioavailability.


NB: To compliment your horse's natural activated B12 balance alongside B6 in P5P form, see our organic plant-sourced B12-Balance supplement.

Key Benefits

✔️ Immune Function: Pyridoxal-5-Phosphate supports antibody and white blood cell production, enhancing the body's ability to fight infections.

✔️ Energy Production: P5P aids in converting carbohydrates, fats, and proteins into usable energy.

✔️ Neurotransmitter Production: P5P helps produce neurotransmitters crucial for mood, cognition, and mental health.

✔️ Haemoglobin Production: P5P is essential for creating haemoglobin, the protein in red blood cells that transports oxygen throughout the body.

B6 in its activated form - P yridoxal-5-Phosphate - is especially critical for the liver's vital role of metabolising toxins. Without it, toxins don't get excreted.

With recent research demystifying a relatively unknown, yet now widespread, equine multi-detoxification disorder, Cryptopyrroluria, aka KPU , it's now known that if the hindgut is in a state of 'acidosis', which triggers the dysbiosis/SIBO/leaky gut domino effect, the natural process of hindgut-produced P5P is disrupted.

This then triggers one heck of a long list of metabolic issues which never seem to go away, despite heroic efforts from owners. See our KPU page for the full story.

NB. P5P also has an essential role in the synthesis of neurotransmitters, including serotonin, dopamine and gamma-aminobutyric acid (GABA).

Composition & Feed Guide

100% pure Pyridoxal-5-Phosphate (P5P) - activated Vitamin-B6.

Feed Guide

  • 1g/day
  • SCOOP PROVIDED - 1-level scoop = 1g
  • A 50g bag will last 1-horse 50-days
  • Human Grade.
  • UK certificate of analysis available on request.

Completely natural, P5P is found in Euglena gracilis , Ginkgo biloba , and other organisms. It’s the active form of vitamin B6 serving as a coenzyme for the synthesis of amino acids , serotonin and norepinephrine neurotransmitters , sphingolipids and aminolevulinic acid.

Reviews

  • 13.5.24 - I just wanted to send you a note to say thank you for all the information you have posted on your website regarding KPU.
    My horse was diagnosed with KPU in 2022 and I started a programme with another company. My horse really struggled with the feed additions and the changes from one week to the next. We would get so far into the programme and then he would literally stop eating his feed completely and this happened more than once. Last year he even had low grade laminitis during the programme and despite doing everything 'right' we were still struggling. I initially took everything away to get him enjoying his feed again. The first nutrient addition I made was activated vitamin B6 and within a few days there was a massive change in him. I was astounded and did more research and came across your website. Thanks to your site I was able to fully understand what KPU was and why the B6 was so important to him, so we are now a couple of weeks into your programme. I was also able to go back and look at his blood tests and using the information you put on your site I was able to understand them better. Anyway I just wanted to say thank you for all the information as that knowledge has really helped me. My horse is enjoying his feed again on your KPU programme so I am very hopeful that we are going in the right direction. Thanks again for all your information! Kindest regards, Sam
  • 24.2.22 - SIBO-CARE, GUTAMINOS & P5P I just ... I dont know what to say, I mean maybe you think I’m a crazy Swede LOL … I think I was hallucinating because after the first morning dose, in the afternoon she already in her eyes and body language looked "better". Her posture was upright, and yesterday afternoon, day 2, she ran like crazy and rolled on the ground and was strong with energy! Today, day 3, she stretched her body (hasn’t done that for a long time) and ate her steamed hay with a good appetite and not just picking through it.The first night my husband said, “Look at her poop! It’s better.” I thought it was maybe just a lucky one, but day 2’s poop is already 50% better in colour and shape. Gas, absolutely better already.C´mon. For real?! LOL … Is it even possible? I know you said you couldn’t promise me anything, but this is too good to be true. I cried this morning because if this is true, then I can already see the light and the hope for this girl and our future. Thank you so much! Janet & Lilly, Sweden
  • 5.2.22 - Foal with major hindgut disruption - Gut Amino’s/P5P/Wildfed
    Powered by you! So so happy with this boy and the way he has turned around in such a short space of time. Zoe & Diego
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