A healthy hindgut biome plays a vital role in equine health, producing essential metabolites (postbiotics) that the horse cannot obtain from food. Among these are two crucial B vitamins, required in their activated forms for proper metabolic function:

• B6 as Pyridoxal-5-Phosphate (P5P) – the only form recognised and utilised by the equine liver.
• B12 as Methylcobalamin – to complement your horse's natural B12 balance alongside P5P. (See our organic plant-sourced B12-Balance supplement for a complete solution.)

Unlike their synthetic counterparts (such as pyridoxine for B6), these activated forms are fully bioavailable - whereas synthetics are treated as toxins and simply excreted.

Why P5P matters

Pyridoxal-5-Phosphate (P5P) is the liver’s preferred, bioavailable form of B6, essential for metabolising toxins and maintaining overall metabolic health.

In horses with hindgut dysbiosis - a condition linked to leaky gut, faecal water syndrome, and chronic inflammation - the natural production of P5P is disrupted, triggering a cascade of metabolic disorders.

By supplementing with P5P, you provide critical support for:

~ Liver detoxification

Without P5P, the liver cannot efficiently process and eliminate toxins.

~ Gut & immune health

Supports a balanced gut biome and healthy immune response.

~ Neurotransmitter synthesis

Essential for the production of serotonin, dopamine, and GABA, supporting mental and emotional well-being.

~ Cellular function

P5P is vital for synthesising amino acids, neurotransmitters, sphingolipids, and aminolevulinic acid, all of which are key to cellular health and overall functionality.

The role of the hindgut microbes

The beneficial microbes in the hindgut biome ferment forage fibre, producing metabolites (postbiotics) essential for health, including:

• Vitamin B6 ( Pyridoxal-5-Phosphate ) – Supports detoxification, metabolism, and neurological health.
• Vitamin B12 ( Methylcobalamin ) – Crucial for red blood cell formation, nerve function, and energy production.

These activated forms are recognised and utilised by the liver, unlike synthetic versions, which are simply treated as toxins and excreted as waste.

For a holistic approach to metabolic health, P5P works synergistically with our B12-Balance supplement, offering a complete solution to support your horse’s natural balance.

Composition

100% pure Pyridoxal-5-Phosphate (P5P) - activated Vitamin-B6.

Feed

• 1g/day
• Scoop included - 1-level 2ml scoop = 1g

Source

• China.
• Human grade.
• UK Certificate of Analysis & Quality Control available on request.