What is KPU?
Cryptopyrroluria (KPU) is a widespread, multi-metabolic detoxification disorder often referred to as "the disease with a thousand faces" due to its extensive range of symptoms. These can include persistent gut issues, skin and hoof problems, musculoskeletal challenges, unexplained swelling, and more.

At its root, KPU stems from a disrupted hindgut microbiome, leading to a deficiency in Pyridoxal-5-Phosphate (P5P), the activated form of vitamin B6. This deficiency impairs the liver's detoxification process, allowing toxins to accumulate and disrupt overall health.

How KPUCOMBO helps
KPUCOMBO provides targeted support to rebalance the hindgut microbiome, restore the gut-liver pathway, and enhance the body's natural detoxification processes.

Key Benefits

🌿 Gut Stabilisation: Neutralises gut pH levels to help rebalance the gut microbiome.

🌿 Hindgut Support: Assists in repairing GI mucosal damage and managing leaky gut/faecal water syndrome.

🌿 Pathogen Microbe Inhibition: Creates a hostile environment for harmful microbes.

🌿 Gas & Bloat Reduction: Helps manage intestinal gas and bloating by reducing pathogen activity.

🌿 Liver & Metabolic Health: Supports adrenal balance, the immune system, glutathione production (the body's master antioxidant), and enhances detoxification.

Important Note

KPUCOMBO is a nutritional, functional food supplement and not veterinary medicine. For more information, refer to Dr Kellon's Horse Sense - Nutrition is not 'Alternative' Therapy .

For the latest KPU updates, see our main A-Z Equine Condition/KPU page in the Advice Centre above.

* Each item is available separately in our KPU Shop page.

Combined Herbal Blend

Human-grade, produced to ecological standards and free from agro-chemicals. See our Quality page for Organic Certification Documents.

A combination of EquiNatural's SiboCARE , GutAminos , P5P (Activated B6), B12-Balance & Spirulina , combined together as one convenient feed supplement.

• 13g/100kg bodyweight per day, i.e. 66g for a 500kg horse.
• For fussy eaters, start with a pinch and slowly build your way up.
• 1-yr shelf life.
  
  

* Supplements of any kind should be fed with caution to the pregnant or nursing mare so always seek veterinary advice.

• If your horse is showing signs of discomfort or stress, alleviate with our our DuoBute / StressTonic.
• Following the KPUCOMBO, feed our LKLCARE to detox and tone the major detoxification organs - the liver, kidneys, and lymph nodes.
• Finally, quality meadow hay , fed 24/7, is going to be your saviour here to help restore the beneficial hindgut microbiome.

Clients have reported transformative results with KPUCOMBO, highlighting improvements in faecal water, energy levels, coat condition, mobility, and overall wellbeing. Horses have shown rapid changes in behaviour, posture, and appetite, with some owners seeing results in just a few days. Highlights includes:

• Dramatic reductions in faecal water and improvements in gut health.
• Significant behavioural changes, including calmer demeanours and increased energy.
• Improvements in coat, hoof quality, and overall physical condition.
• Positive impacts on musculoskeletal health and mobility.