What is KPU?
Cryptopyrroluria (KPU) is a widespread, multi-metabolic detoxification disorder often referred to as "the disease with a thousand faces" due to its extensive range of symptoms. These can include persistent gut issues, skin and hoof problems, musculoskeletal challenges, unexplained swelling, and more.

At its root, KPU stems from a disrupted hindgut microbiome, leading to a deficiency in Pyridoxal-5-Phosphate (P5P), the activated form of vitamin B6. This deficiency impairs the liver's detoxification process, allowing toxins to accumulate and disrupt overall health.

How KPUCOMBO helps
KPUCOMBO provides targeted support to rebalance the hindgut microbiome, restore the gut-liver pathway, and enhance the body's natural detoxification processes.

For the latest KPU updates, see our main A-Z Equine Condition/KPU page in the Advice Centre above.

Each item is available separately in our KPU Shop page.

Human grade, produced to ecological standards and free from agro-chemicals. See our Quality page for Organic Certification Documents.

• 13g/100kg bodyweight per day, i.e. 66g for a 500kg horse.
• For fussy eaters, start with a pinch and slowly build your way up.
• 1-yr shelf life.

Comprising: A combination of EquiNatural's SiboCARE , GutAminos , P5P (Activated B6), B12-Balance & Spirulina , combined together as one convenient feed supplement.

Important Note: Supplements of any kind should be fed with caution to the pregnant or nursing mare so always seek veterinary advice.

• If your horse is showing signs of discomfort or stress, alleviate with our our DuoBute / StressTonic.
• Following the KPUCOMBO, feed our LKLCARE to detox and tone the major detoxification organs - the liver, kidneys, and lymph nodes.
• Finally, quality meadow hay , fed 24/7, is going to be your saviour here to help restore the beneficial hindgut microbiome.

Clients have reported transformative results with KPUCOMBO, highlighting improvements in faecal water, energy levels, coat condition, mobility, and overall wellbeing. Horses have shown rapid changes in behaviour, posture, and appetite, with some owners seeing results in just a few days. Highlights includes:

• Dramatic reductions in faecal water and improvements in gut health.
• Significant behavioural changes, including calmer demeanours and increased energy.
• Improvements in coat, hoof quality, and overall physical condition.
• Positive impacts on musculoskeletal health and mobility.

Notable feedback:

An update on Sid the mini shetland - he came off the antibiotic, bute, steroids - he had survived but was not in a good way - he really came back to life, chasing his stable mate and just racing round the school for the joy of it – he was showing more energy than ever before. He then went onto the LKL CARE with continued gutaminos - mid June - mid July, then he went onto BiomeTonic. During this time he has not only grown he has also put on much needed weight. He is a transformed pony and is better than we hoped he might ever get to. I want to say a big thankyou to you for your advice and the herbs. Best wishes.

I thought I would update you with my boys progression.I rode him last week and he was the ‘sparkliest’ he has been for years. He was happy and not spooky and trotted up a hill (I’ve not done that in years). I am able to ride him now 5 times a week with no problem.He has not had any mud fever this winter, his mallanders have almost gone, his hooves look in great shape and his overall coat condition looks fantastic! He's now out by night with a muzzle and in by day with hay. I take him for hedgerow graze every day (self service medicine cabinet). Still a way to go - there's still a bit of bloat and round the belly but he has a flat bum (no heart shape) and no more cresty neck. Natalie & Dewi

Just a little update on the boys. Des continues to do extremely well with not a sign of any faecal water, he’s so happy in himself and really cheeky and naughty. He loves going out for his walks and playing with Kermit. We really can’t thank you enough for all your help and advice, what your products have done for our boys has been amazing and we are so grateful. Long may it continue.Thanks again, Cathy

Started Honey on your protocol yesterday and I'm absolutely amazed, for the first time in months she is like a different horse in the stable...she used to be extremely food-guardy to the point that I could hardly get near her if there was hay around, without pinned ears, a squeal, and even a kick. She was so incredibly calm this morning, was happy for me to change her rug and faff around next to her whilst she ate her hay, her demeanor has changed so much. I wasn't expecting to see such quick results! It is obviously really helping her, I'm incredibly grateful, especially as no other products have helped her so far - I was starting to lose hope.Best wishes, Rachel & Honey

* Edited to add - Hi Carol, Just had to send another update today as I am so amazed at Honey's transformation. In the past I have not been able to handle her at all in the stable, due to how sensitive she was at being touched. Even rugging her had to be done tied up outside. Today it was pouring with rain and I thought I'd try tacking her up in the stable. Bear in mind that I haven't done this for 6+ months, and in the past she would bite and kick at me (so obviously I stopped riding her or doing any of these things, as it was clear she was not happy).Well, today I tacked her up in the stable, completely loose. She did not walk away from me, did not flinch in the slightest at the girth, but stood happily to be tacked up. This was whilst eating hay, which in the past she would guard and not let me anywhere near. She has only been on the full dose of SIBOCare and GutAminos for 2 days, I'm so amazed at the transformation. Thank you so so much, hopefully things will keep continuing in the right direction!

Just wanted to touch base with you because I’m delighted to say Charlie and Alfie are both completely different from when I first contacted you. I threw myself in100% with all your advice and it totally paid off. The supplements got them right back on track. They are now both turned out 24/7 which I thought would never happen again. They have constant access to late cut hay and now have a big track around the field to graze with huge hedges available to graze from. They’re lightly rugged when needed and have access to their stables at all times. Currently they have just a handful of the agrobs chaff you recommended with their equivita once daily. Both boys have stopped peeing dark brown and it’s clear now instead. Charlie’s energy is fabulous - he’s gone from hardly having the will to trot to being back to his fiesty self! I forgot how amazing he feels. There’s so much power in his tank it’s great. We’ll definitely be eventing again later in the year, which is so wonderful as I really believed his career was over at the end of last year. I even had to sort him out with better brakes as they massively failed the other day! Alfie is feeling lovely too, far more sensible and not storming off. Both boys have lost their bulgy bits over their eyes and the hollows have returned. Also Charlie’s sheath is no longer swollen. They’re glossy and shiny and happy. I’ve noticed that their feet are so much better too and Charlie is now able to cope with stoney ground miles better than he ever has before. (I’ve owned him 14yrs). So, thankyou so much for all your advice, it’s been wonderful to watch the boys improve so well. You’ve been full of such wonderful knowledge and advice. I’m not sure what I would have done without you. Marion

Annie has been going great guns on your KPU plan now, the difference in her is amazing. She has many days now with no faecal water at all and when she does it is minimal compared to what it was and her actual faeces is formed balls. 9 times out of 10 it doesn’t smell like and she is going a lot less too. Megan & Annie

I just ... I dont know what to say, I mean maybe you think I’m a crazy Swede LOL … I think I was hallucinating because after the first morning dose, in the afternoon she already in her eyes and body language looked "better". Her posture was upright, and yesterday afternoon, day 2, she ran like crazy and rolled on the ground and was strong with energy! Today, day 3, she stretched her body (hasn’t done that for a long time) and ate her steamed hay with a good appetite and not just picking through it.The first night my husband said, “Look at her poop! It’s better.” I thought it was maybe just a lucky one, but day 2’s poop is already 50% better in colour and shape. Gas, absolutely better already.C´mon. For real?! LOL … Is it even possible? I know you said you couldn’t promise me anything, but this is too good to be true. I cried this morning because if this is true, then I can already see the light and the hope for this girl and our future. Thank you so much! Janet & Lilly, Sweden

Thank you SO much for your help with Rupert's faecal water situation. He is like a different horse, much happier, not uncomfortable and churning out less and better formed poos. What more could I wish for?? Barbara & Rupert