P5P B6 (Activated form) - Pyridoxal-5-Phosphate (50g)
We know that the beneficial microbes in the gut microbiome provide essential services for the host; they digest the food and assimilate the nutrients, as well as protecting against bacteria that cause illnesses.
The hindgut microbiome also produces important nutrients (postbiotics), including vitamin K and two of the vital B-vitamins - B6 and B12 - in a specific 'activated' form that the gut nutrient-absorbing receptors recognise, unlike the regular B-vitamins found in a supplements. Namely B12, commonly known as Cobalamin, is produced by the hindgut microbes in its activated form as Methyl-cobalamin, and B6, commonly known as Pyridoxine, is produced by the hindgut microbes as Pyridoxal-5-Phosphate.
With recent research demystifying an equine multi-detoxification disorder, Cryptopyrroluria, aka KPU, it's now known that if the hindgut is in a state of 'acidosis', triggering the dysbiosis/SIBO/leaky gut domino effect, the natural process of hindgut-manufactured P5P is disrupted, which directly and adversely affects the liver’s vital biotransformation role, because the liver needs P5P, not pyridoxine, to do this.
If the liver becomes deficient in P5P, this causes one heck of a long list of metabolic issues which never seem to go away, despite heroic efforts from owners.
- Human-grade powder-form vitamin B6 Pyridoxal-5-Phosphate (P5P)
- 1g/day - 1 level teaspoon
- A 50g bag will last 1-horse 50-days