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Allergy response v. the microbiome


Allergic diseases are becoming more widespread and increasing in prevalence, with many studies now showing that the typical progression of allergy responses begins early in life, although there’s no doubt that there are other factors at play.

There’s also no doubt that the gut microbiota play a leading role in shaping early immune responses - science is now showing that there are allergy-protective bacteria in the microbiome! That said, I'm sure it'll come as no surprise that it’sall about environmental and lifestyle factors which impact the formation of a diverse microbiota, both skin and GI tract, with the usual suspects being a poor-quality diet, early-life antibiotics/overuse of antibiotics, dust/mould, and outdoor air-pollution, i.e. crop spraying.

Sadly, intestinal dysbiosis in youngstock is now common, inhibiting the natural production in the gut of important SCFAs (short chain fatty acids) such as butyrate, acetate, and propionate. These SCFAs are not only anti-inflammatory, but they also act as an energy source for specific gut microbes known as ‘colonocytes’ which shape the beneficial gut microbiota diversity. They’re also key drivers of T-cell proliferation and activity, T-cells being part of the immune system that focus on specific antigens, playing a critical part in immunity to foreign substances.

As for dust and mould, surprisingly the data is showing that endotoxin levels in the air aren't that different between farming and urban environments, but endotoxins in dust are much higher around farms.

This all collectively emphasises the microbiome’s influence on systemic aspects of the immune response - supporting a healthy microbiome is key for strengthening immune responses and increasing toxicant elimination. Examples include focusing on:


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